Notes: 1:Clickable 2:Unclickable TRAF2/5 TRAF6 TRAF6 TRAF2/6 TRAF2/6 TRAF2/6 TRAF2/6 TRAF6 TRAF6 TAX1BP1 K63-linkedPolyubiquitin RlP1 RlP1 E1Ubc13/Uev1A A20 E1Ubc13/Uev1A A20CYLD E1Ubc13/Uev1A A20CYLD K48-linkedPolyubiquitin TNFR1 IL1R/TLR TCR/BCR TAB2/3 TAK1 TAB2/3 TAK1 TAB2/3 TAK1 α Tax NEMO Cytoplasm Nuclear IL-6 CYLD NEMO RNF11 Itch A20 A20 Ubiquitin-editing Complex A20 IкBα P {{ board.text }} {{ board.text }} {{ board.text }} {{ board.text }} {{ group.title }} {{ text.text }} {{ button.text }} IKKα IKKβ P P P P {{ group.title }} {{ text.text }}