+ MYD88 JAK-STAT NF-κB IRAK pSTAT3 p38 MAPK IRS1 SOCS3 PI3K pAkt PKCθ/PP2A SIRT1 PDH ACC AMPK CAMKKβ CDK5 PPARγ SIRT1 PGC-1α PPARγ pCREB PPARγ C/EBPβ C/EBPα LKB1 TCS1/2 mTORC JNK TRAF6 IKK NEMO PKA Lipolysis Lipogenesis Adiponectin HIF-1αDestabilization GlycerolNeogenesis Glut4Translocation Autophagy BCAACatabolism Adipocyte-specificGene Expression NF-κB-mediatedInflammation Chaperones RegulatingAdiponectin Secretion MitochondrialBiogenesisProgram FAOxidation OXPHOS NormalOxidativeStress LPL HSL MGL ATGL CGI-58 TNFα FATP FAs FAs CD36 ATP Glucose O 2 (Normoxia) Caveolins LipoproteinParticles SNS Signaling β3AR Glucose TNFR Insulin R M2 Macrophage IL-10(Anti-inflammatory) Insulin Adipo R S1P S1PR S1P Ca 2+ BCAAs GOLGI Malonyl-CoA Acetyl-CoA Glucose Perilipins Pyruvate LIPIDDROPLET CPT1 [AMP:ATP] UCP1 Citrate ROS ROS Cytosol Nucleus NAD + /NADH Acetyl-CoA Mitochondria(Normal Function) Ceramide Ceramide FGF21 IL-6 SaturatedFAs TLR4 FGFRs/βKlotho AdiponectinRelease (to OtherOrgans) Glut4 SLC6 gp130 IL-6R gp130 AC Gsα cAMP TG FSP27 CIDEA InsulinSignaling PKA InhibitorH 89PKA ActivatorsDibutyryl-cAMP8-Bromo-cAMP Pan-Akt InhibitorsMK-2206IpatasertibCapivasertibAkt ActivatorSC79Selective Akt InhibitorsA-674563 (AKT1)CCT128930 (AKT2) TNF-alpha InhibitorsPomalidomideLenalidomide PPARγ AntagonistsT0070907GW9662PPARγ AgonistsRosiglitazonePioglitazoneTroglitazone mTOR InhibitorsRapamycinEverolimusAZD8055Torin 1SapanisertibmTOR Agonist3BDO P {{ board.text }} FAs CD36 Lipolysis Caveolins Glucose Glucose Glucose SNS Signaling TNFR Insulin R Adipo R Adiponectin S1P S1P M2 Macrophage BCAAs FGF21 TLR4 CIDEA FSP27 FAs Lipogenesis ATP TG Perilipins Cytosol Nucleus (Normoxia) O 2 NAD /NADH + Pyruvate Ceramide Ceramide [AMP:ATP] GOLGI OXPHOS Citrate PDH ROS ROS CPT1 UCP1 Ca 2+ FATP Glut4 SLC6 gp130 IL-6R gp130 Lipoprotein Particles IL-10 (Anti-inflammatory) Adiponectin Release (to Other Organs) FGFRs/ βKlotho Saturated FAs Glycerol Neogenesis LIPID DROPLET Insulin Signaling HIF-1α Destabilization Mitochondrial Biogenesis Program Normal Oxidative Stress Chaperones Regulating Adiponectin Secretion Adipocyte-specific Gene Expression NF-κB-mediated Inflammation Glut4 Translocation Mitochondria (Normal Function) Acetyl- CoA Malonyl- CoA BCAA Catabolism FA Oxidation Acetyl- CoA {{ board.text }} {{ board.text }} {{ group.title }} {{ text.text }} {{ button.text }} {{ group.title }} {{ text.text }} Notes: 1:Clickable 2:Unclickable