Notes:
1:Clickable
2:Unclickable
Growth Factors
Glucose
NADH
AMPKActivation
Nicotinamide
Ribose
AMP
ADPR
Units
ADPR
Units
Poly ADP-Ribose
Live Cell
PARP
Cleavage
Normal Function
Loss of Function
Cancer
ADP-Ribose
Units
Other DNA
Repair
Enzyme
DNA Repair
High Damage
Low Damage
ATP / NAD
Depletion
Necrosis
Apoptosis
Initiation Event
Caspase-3 Activation
Znl
Zn
Ⅱ
Znlll
BRCT
WGR
H Y
E
*
*
*
NLS
DBD
AD
Catalytic Domain
Other Unknown Targets
ATP
ARH3
PARG
TSC2
TSC1
Class IPI3K
Atg4A
ROS
ROS
Atg1-Atg13Complex
Viable with
No Mutation
Viable with
Mutation
Genotoxin
Raptor
P ARP
mLST8
XRCC1
Histone H1
MRE11
ADP
Modulate PARP
Activity
Modulate PARP
Activity
Recruitment of XRCC1 and DNA ligase III to SSBs and repair by BER.
Altered chromatin binding during DNA damage and transcription.
DSB repair by NHEJ.
DSB repair by HR and checkpoint activation.
HR and restarting of collapsed replication forks.
Genomic maintenance.
NAD
Transient Recruitment
and Non-covalent and
Covalent Modifications
of Various Proteins
P
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