MHC Class IPeptide Presentation
TERT Peptide-specificT-cell Receptor
Antigen-presenting Cell
• TERT Peptide(s)• TERT mRNA• TERT DNA Vectors
TERT Immunotherapy
TERT Peptide Presentationto CD8 (or CD4) Cells
CD8
+
Cytotoxic T Cell
Co-regulatory Signals
TERT Promoter-drivenSuicide Gene Therapy
TERT Peptides
Golgi
Cell Lysis
Endoplasmic Reticulum
Telomere-associatedProteins
Telomere-disruptingAgents
DNA
Tumor Cell
TelomeraseTurnover
Assembly
Processing
Translation
Processing
Block TelomeraseExpression orBiogenesis
hTRTERTTranscription
TelomeraseGenes
Active site
Template
Dyskerin
hTR
TTAGGGTTAGGGTTAGGGTTAG
AUCCCAAUC
chr.3
chr.5
5′
3′
P
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