E E E E L L C C C C C C C C C C C F F F F F F F F F F F F F F F F F A A F Kinase Fibronetin Cysteine Rich Leucine Rich EGF-Like Acid Box Cadherin IG-Like Glycine Rich EGFR HER2/ErbB2 ErbB3 ErbB4 INSR IGF-1R IRR FGFR PDGFR CSF-1R Kit FLT3 VEGFR Met Ron Sea TrkA TrkB TrkC Tie Tie-2 Eph Eck Eek Erk Elk Ros Ret Ltk ALK PLC PDK-1 Akt PKC IKK Syk Bcr-Abl Ras Raf c-Src GSK-3 c-Jun c-Fos JAK ROCK Rho PAK JAK STAT PI3K/AktPathway NF-κBPathway MAPKPathway Cell Cycle JAK/STATPathway HER2/ErbB2 InhibitorsCP-724714AfatinibDacomitinib Pan-EGFR InhibitorsAfatinibLapatinibSapitinibSelective EGFR InhibitorsErlotinib (EGFR/ErbB1)CP-724714 (HER2/ErbB2)Mutant EGFR InhibitorsOsimertinibGefitinib Pan-FGFR InhibitorsBGJ398AZD4547ErdafitinibSelective FGFR InhibitorsPD173074 (FGFR1)H3B-6527 (FGFR4) Pan-PDGFR InhibitorsImatinibCrenolanibCP-673451Selective PDGFR InhibitorsSunitinib (PDGFRβ)Avapritinib (PDGFRα) c-Kit InhibitorsSitravatinibMasitinibAmuvatinibDovitinib Pan-VEGFR InhibitorsAxitinibRegorafenibNintedanibLenvatinibSelective VEGFR InhibitorsCabozantinib (VEGFR2)Anlotinib (VEGFR2)SAR131675 (VEGFR3) Tie-2 InhibitorsTie2 kinase InhibitorCabozantinib c-RET InhibitorsAD80GSK3179106 ALK InhibitorsBrigatinibCeritinibLorlatinibAlectinibRepotrectinib IGF-1R InhibitorsLinsitinibGSK1904529ABMS-754807Picropodophyllin c-Met InhibitorsCrizotinib (PF-02341066)CapmatinibForetinib BMS-777607PHA-665752Savolitinib Pan-Trk InhibitorsLarotrectinibEntrectinibSelitrectinibSelective Trk AntagonistANA-12 (TrkB)Selective Trk Agonist 7,8-Dihydroxyflavone (TrkB) P Cell Cycle MAPK Pathway PI3K/Akt Pathway NF-κB Pathway JAK/STAT Pathway Kinase Fibronetin Cysteine Rich Leucine Rich EGF-Like Acid Box Cadherin IG-Like Glycine Rich Tie Eph Eck Eek Erk Elk Ros Ltk Sea IRR I II III IV V VI VII {{ board.text }} {{ board.text }} {{ group.title }} {{ text.text }} {{ button.text }} {{ group.title }} {{ text.text }} Notes: 1:Clickable 2:Unclickable