P
P
P
P
P
P
P
P
P
P
P
P
Ub
Ub
Ub
Ub
P
IntracellularVesicle
PI3K
APC
Smo
Akt
Hedgehog
PKA
GSK-3β
GSK-3β
GSK-3β
PKC
JNK
HDAC
STAT3
TAK2
STAT3
STAT3
MAPK
Caspase-3
STAT3
Smad1
Smad4
Smad1
Smad4
FGFR
β-cat
β-cat
β-cat
β-cat
TGFβ
Wnt
Rac
BMP
SUFU
GRK
CKI
Axin
Axin
αi
α
γ
Gli
Gli
NFAT
API
β
γ
β
DSH
Rho
PLC
SHARP
SMRT
CtBp
Nicd
CSL
Nicd
CSL
Hes1
Hes1
LIF
Cdx2
Gata6
Others
Ronin
P300
Mam
TCF/LEF
α
(cAMP)
Ca
2+
PTC
Frizzled
GTP
GTP
GTP
γ-Secretase
Proteasome
LIFR
gp130
FGF
Gfap
Idl
Translocation
S2
ADAM17
Sanpodo
TGFβRⅠ,TGFβRⅡ
Gene Expression
E(Spl)
Hey
Herp2
Hey
Hes1
Hey1
Hes1
Dll1,3,4/Jagged1,2
Hedgehog InhibitorsCyclopamineVismodegib
Smoothened AntagonistsCyclopamineSonidegibSmoothened AgonistsSmoothened Agonist (SAG)Purmorphamine
Pan-TGF-beta/Smad InhibitorsLDN-193189K02288Selective TGF-beta/Smad InhibitorsSB431542 (ALK5)Galunisertib (TGF-βRI)
GSK-3β InhibitorsTWS119TideglusibAR-A014418
Gamma-secretaseInhibitorsDAPTRO4929097CrenigacestatLY411575DibenzazepineNirogacestat
Pan-STAT InhibitorSH-4-54Selective STAT InhibitorsFludarabine (STAT1)Stattic (STAT3)C188-9 (STAT3)AS1517499 (STAT6)