NodalR I
Angiogensis, Extracellular Matrix,Neurogenesis, Immunosuppression,Apoptosis Induction
G1 Arrest
Gonadal Growth,Embryo Differentiation,Placenta Formation, etc.
Osteoblast Differentiation,Neurogenesis,Ventral Mesoderm Specification
DNA
DNA
DNA
DNA
Transcription Factors,Co-activatorsand Co-repressors
TAK1, MEKK1,DAXX/JNK
Protein Synthesis
Ubiquitin MediatedProteolysis
DNA
DNA
Left-right Axis Determination,Mesoderm and Endoderm
Nodal
Activin A,B,C
TGFβ1,2,3
TGFβ
BMP2,4
BMPR II
NodalR II
Smad6/7
Smurf1/2
Smad7
PP2A
Smad6/7
Pitx2
SP1
DP1
E2F4/5
p107
p15
Skp1
Rbx1
Cul1
SARA
Id
P
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Notes:
1:Clickable
2:Unclickable