| S1647 |
Adenosine |
Adenosine是一种核苷，包含腺嘌呤，通过β-N9-糖苷键，与核糖分子（呋喃核糖的）部分连接。 |
| S2475 |
Imatinib |
Imatinib是一种多靶点酪氨酸激酶抑制剂，抑制v-Abl、c-Kit和PDGFR的IC50分别为0.6，0.1和0.1 μM。Imatinib (STI571) 可诱导自噬。 |
| S1833 |
Butoconazole nitrate |
Butoconazole nitrate (RS-35887)是一种抗真菌剂，抑制PHA刺激下人外周血淋巴细胞中细胞因子（如IL-2, TNFα, IFN 和 GM-CSF）的分泌，IC50分别为7.2 μg/mL, 14.4 μg/mL, 7.36 μg/mL 和 7.6 μg/mL。 |
| S1282 |
Artemisinin |
Artemisinin青蒿素用于治疗耐多药的恶性疟疾菌株。 |
| S3207 |
Iopromide |
Iopromide是一种水溶性的亲水的非电离的造影剂，用于x-射线成像。 |
| S3727 |
Vilanterol Trifenate |
Vilanterol trifenatate (GW642444M) is a novel inhaled long-acting beta2 adrenoceptor agonist with inherent 24-hour activity for once daily treatment of COPD and asthma. |
| S3657 |
Promestriene |
Promestriene (3-propyl ethyl, 17B-methyl estradiol) is a synthetic estrogen analog that has been reported to significantly improve the symptoms of vaginal atrophy caused by estrogen deprivation in topical application. |
| S3673 |
Sulfaphenazole |
Sulfaphenazole (Depocid, Depotsulfonamide, Plisulfan, Raziosulfa) is an inhibitor of CYP2C9 with Ki value of 0.3 μM and demonstrates at least 100-fold selectivity over other CYP450 isoforms (Ki values of 63 and 29 μM for CYP2C8 and CYP2C18, respectively, and no activity at CYP1A1, CYP1A2, CYP3A4, CYP2C19). |
| S3726 |
Selexipag |
Selexipag (NS-304, ACT-293987) is an orally active, first-in-class, selective prostacyclin IP receptor agonist with Ki value of 260 nM for human IP, whereas Ki values > 10,000 nM are measured at the other human G-protein-coupled prostanoid receptors (EP1-4, DP, FP and TP). |
| S3728 |
Grazoprevir |
Grazoprevir anhydrous (MK5172) 是一种 Hepatitis C Virus NS3/4A Protease 的抑制剂，HCV genotype 1a、1B和4的IC50值分别为7pM、4pM和62pM。 |
| S3731 |
Tipiracil hydrochloride |
Tipiracil (MA-1)是一种 thymidine phosphorylase的抑制剂，该酶可将三氟吡啶降解为三氟胸苷。它与三氟吡啶的组合可增加三氟吡啶的生物利用度。 |
| S3671 |
Quinestrol |
Quinestrol (Ethinylestradiol 3-cyclopentyl ether, EE2CPE, W-3566) is a synthetic, steroidal estrogen which is used in hormone replacement therapy and occasionally to treat breast cancer and prostate cancer. |
| S3667 |
Imipenem |
Imipenem acts as an inhibitor of AmpC β-lactamase and is an antibiotic useful for the treatment of a number of bacterial infections. |
| S3716 |
Flibanserin |
Flibanserin (BIMT-17, BIMT-17-BS) 是一种非激素类、作用于中枢的小分子，是突触后5-HT1A受体的激动剂，也是5-HT2A的拮抗剂。 |
| S3732 |
Avibactam sodium |
Avibactam (AVE-1330A, NXL104) is a covalent, reversible, non-β-lactam β-lactamase inhibitor with IC50 values of 8, 80, and 38 nM for TEM-1, P99, and KPC-2 β-lactamases, respectively. |
| S3714 |
Lifitegrast |
Lifitegrast (SAR1118,SHP-606)是一种新型的integrin拮抗剂，抑制参与DED病理形成中的特定的T细胞介导的炎症途径。 |
| S3724 |
Velpatasvir |
Velpatasvir (GS-5816,VEL) 是二代NS5A抑制剂，抑制丙型肝炎病毒（HCV）的复制。 |
| S3735 |
Umeclidinium bromide |
Umeclidinium bromide(GSK573719A)是一种长效毒蕈碱拮抗剂，对治疗慢性阻塞性肺疾病具有持续性疗效。 |
| S3746 |
Lumefantrine |
Lumefantrine (benflumetol) 是一种抗疟疾剂，用于治疗急性无并发症的疟疾。 |
| S3745 |
Balsalazide disodium |
Balsalazide Disodium 是balsalazide的二钠盐形式，balsalazide是一种口服的对氨水杨酸钠前体药物，在结肠中被酶解、产生抗炎性的美沙拉秦（mesalazine）。Balsalazide Disodium 通过调节 IL-6/STAT3 途径抑制结肠炎相关的癌变。 |
